View abstract. 11-9-2008; Colman, N., Larsen, J. V., Barker, M., Barker, E. A., Green, R., and Metz, J. View abstract. A., Siebelink, E., Katan, M. B., and Verhoef, P. Bioavailability of food folates is 80% of that of folic acid. The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. View abstract. Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma. Aliment.Pharmacol.Ther 2010;31(7):708-718. Berg MJ, Stumbo PJ, Chenard CA, et al. Smithells, R. W. Can vitamins prevent neural tube defects? View abstract. Folate deficiency. Gaziano JM, Glynn RJ, Christen WG, et al. View abstract. View abstract. 2008;17(12):3444-3449. Washington, DC: The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists; 2012. J Thromb Thrombolysis 2012;34(4):459-67. View abstract. Zhu, S., Mason, J., Shi, Y., Hu, Y., Li, R., Wahg, M., Zhou, Y., Jin, G., Xie, Y., Wu, G., Xia, D., Qian, Z., Sohg, H., Zhang, L., Russell, R., and Xiao, S. The effect of folic acid on the development of stomach and other gastrointestinal cancers. N.Engl.J.Med. Wu, K., Platz, E. A., Willett, W. C., Fuchs, C. S., Selhub, J., Rosner, B. Cronin, S., Furie, K. L., and Kelly, P. J. Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Am J Obstet.Gynecol. View abstract. Ma F, Li Q, Zhou X, et al. Am J Clin Nutr 2007;85(2):465-473. View abstract. Rosado, J. L., Gonzalez, K. E., Caamano, Mdel C., Garcia, O. P., Preciado, R., and Odio, M. Efficacy of different strategies to treat anemia in children: a randomized clinical trial. Diabetes Res Clin Pract. View abstract. 2003;5(4):315-322. View abstract. View abstract. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. 2012;46(10):1349-1357. Jensen, O. N. and Olesen, O. V. Subnormal serum folate due to anticonvulsive therapy. Circulation 2002;(106):741S. Am J Med 2002;112:535-9.. View abstract. Yakoob, M. Y., Menezes, E. V., Soomro, T., Haws, R. A., Darmstadt, G. L., and Bhutta, Z. Arch Neurol 2007;64:86-92. Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy). Vergel, R. G., Sanchez, L. R., Heredero, B. L., Rodriguez, P. L., and Martinez, A. J. View abstract. Cancer Lett. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Arch Int Med 1983;143:902-4. Koppen, I. J., Hermans, F. J., and Kaspers, G. J. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. At this stage, most women do not know they are pregnant. Pastore, A., De, Angelis S., Casciani, S., Ruggia, R., Di, Giovamberardino G., Noce, A., Splendiani, G., Cortese, C., Federici, G., and Dessi', M. Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes. Folic acid (also known as folate or folacin) is a B vitamin. BMC Geriatr 2013;13:88. View abstract. View abstract. Clinical review: Cardiovascular consequences of ovarian disruption: a focus on functional hypothalamic amenorrhea in physically active women. View abstract. Figueiredo, J. C., Levine, A. J., Grau, M. V., Barry, E. L., Ueland, P. M., Ahnen, D. J., Byers, T., Bresalier, R. S., Summers, R. W., Bond, J., McKeown-Eyssen, G. E., Sandler, R. S., Haile, R. W., and Baron, J. Riddell LJ, Chisholm A, Williams S, Mann JI. View abstract. Am J Med Sci. Take one tablet a day, with a meal. 2013 1;133(5):1033-41. Cochrane Database Syst Rev. BMC.Public Health 2007;7:136. View abstract. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Vianna, A. C., Mocelin, A. J., Matsuo, T., Morais-Filho, D., Largura, A., Delfino, V. A., Soares, A. E., and Matni, A. M. Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events. Vitamins E and C in the prevention of prostate total cancer in men: the physicians' health study II randomised controlled trial. There is some evidence that increasing folic acid and folate intake from dietary and supplement sources, along with thiamine, riboflavin, and vitamin B12, might help to prevent cancer of the cervix. A metaanalysis of randomized controlled trials. J.Clin Neurosci. Have you eaten any leafy greens recently? Bhutta, Z. Nutr.Cancer 2003;46(2):131-137. View abstract. 2019 Jul;311(5):361-367. Lancet 2-3-1990;335(8684):293. Oral Surg Oral Med Oral Pathol 1991;70:565-8. Tjonneland, A., Christensen, J., Olsen, A., Stripp, C., Nissen, S. B., Overvad, K., and Thomsen, B. L. Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. 2014;8(1):61-8. The controversy over homocysteine and cardiovascular risk. Cancer Epidemiol.Biomarkers Prev. Vermeulen EG, Stehouwer CD, Twisk JW, et al. View abstract. Halsted, C. H., Villanueva, J. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. B., Ueland, P. M., Nesthus, I., Nygard, O., Schneede, J., Vollset, S. E., and Refsum, H. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. J Obstet.Gynaecol.Br Commonw. Fletcher, J., Gurr, A., Fellingham, F. R., Prankerd, T. A., Brant, H. A., and Menzies, D. N. The value of folic acid supplements in pregnancy. J.Alzheimers.Dis. Whether you need it for dietary supplementation in pregnancy, heart health, or general health, this is an excellent folic acid supplement. Obstet Gynecol 2000;95:519-24. Curr Med.Res Opin. Am.J.Epidemiol. View abstract. Diabete Metab 1976;2:187-90. View abstract. De, Wals P., Tairou, F., Van Allen, M. I., Uh, S. H., Lowry, R. B., Sibbald, B., Evans, J. View abstract. Am J Clin Nutr 2014;100(6):1578-86. Safrin S, Lee BL, Sande MA. Tomaszewski JJ, Richman EL, Sadetsky N, O'Keefe DS, Carroll PR, Davies BJ, Chan JM. Ebbing, M., Bleie, O., Ueland, P. M., Nordrehaug, J. E., Nilsen, D. W., Vollset, S. E., Refsum, H., Pedersen, E. K., and Nygard, O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. View abstract. 2006;63(11):1545-1550. Lancet Neurol. Proc.Nutr.Soc. Allen, L. H., Peerson, J. M., and Olney, D. K. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. Pathansali, R., Mangoni, A. Kim, D. H., Smith-Warner, S. A., Spiegelman, D., Yaun, S. S., Colditz, G. A., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Graham, S., Harnack, L., Jacobs, E. J., Leitzmann, M., Mannisto, S., Miller, A. View abstract. J Am Coll Cardiol 2001;38:1799-805.. View abstract. Usually ships within 1 to 2 months. Arch.Dis.Child 1981;56(12):911-918. Circulation 3-30-2010;121(12):1432-1438. N.Engl.J Med 9-19-1985;313(12):709-715. View abstract. View abstract. The interventional effect of folic acid on the development of gastric and other gastrointestinal cancers - Clinical trial and follow- up for seven years. View abstract. B., van der Merwe, A., Vermaak, W. J., and Delport, R. Hyperhomocysteinemia and the response to vitamin supplementation. View abstract. View abstract. Effect of folate on phenytoin hyperplasia. View abstract. View abstract. Montagnani, F., Chiriatti, A., Turrisi, G., Francini, G., and Fiorentini, G. A systematic review of FOLFOXIRI chemotherapy for the first-line treatment of metastatic colorectal cancer: improved efficacy at the cost of increased toxicity. Br J Cancer. Lopez-Jaramillo, P., Narvaez, M., Felix, C., and Lopez, A. Dietary calcium supplementation and prevention of pregnancy hypertension. J Am Med Assoc 1980;244:633-4. View abstract. Marcucci, R., Zanazzi, M., Bertoni, E., Rosati, A., Fedi, S., Lenti, M., Prisco, D., Castellani, S., Abbate, R., and Salvadori, M. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Clarke, R. and Collins, R. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? 5'-methyltetrahydrofolate, 5'-methyltetrahydrofolic acid, 5'-MTHF, Acide Folique, Acide Ptéroylglutamique, Acide Ptéroylmonoglutamique, Acido Folico, B Complex Vitamin, Complexe de Vitamines B, Complexe Vitaminique B, Dihydrofolate, Dihydrofolic Acid, Folacin, Folacine, Folate, Folinic Acid, L-methylfolate, Methylfolate, Méthylfolate, Methylfolic Acid, Pteroylglutamic Acid, Pteroylmonoglutamic Acid, Pteroylpolyglutamate, Tetrahydrofolate, Tétrahydrofolate, Vitamin B9, Vitamine B9. Failure of pretreatment with intravenous folic acid to alter the cumulative hematologic toxicity of lometrexol. View abstract. Olthof, M. R., Bots, M. L., Katan, M. B., and Verhoef, P. Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. The influence of folate and multivitamin use on the familial risk of colon cancer in women. View abstract. View abstract. Potential toxic side effects of folic acid (letter). View abstract. View abstract. van der Griend R, Biesma DH, Haas FJLM, et al. Eur J Clin Pharmacol. If you forget a dose, take it as soon as you remember. Int.Urol.Nephrol. Worthington, H. V., Clarkson, J. E., and Eden, O. Hofstad, B., Almendingen, K., Vatn, M., Andersen, S. N., Owen, R. W., Larsen, S., and Osnes, M. Growth and recurrence of colorectal polyps: a double-blind 3-year intervention with calcium and antioxidants. View abstract. View abstract. Cancer Epidemiol.Biomarkers Prev. Montes LF, Diaz ML, Lajous J, et al. B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. View abstract. PLoS.Clin Trials 2006;1(2):e10. Psychol.Med 1971;1(2):166-171. View abstract. Leeb BF, Witzmann G, Ogris E, et al. When higher doses are needed. It comes in powder form, so an accurate milligram scale is required to measure the correct folic acid supplement dosage. Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid: Rare. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Adverse neuropsychiatric effects of anticonvulsant drugs. Am.J.Clin Nutr. Risk factors for gout and prevention: a systematic review of the literature. Taking folic acid during pregnancy does not seem to reduce the risk of having a baby die just before or after birth. View abstract. Cole B, Baron J, and Sandler R. A randomized trial of folic acid to prevent colorectal adenomas. Drugs 1994;48:137-52. Scand J Clin Lab Invest 1988;48:215-21. View abstract. View abstract. A type of throat cancer (pharyngeal cancer). Clin Nephrol 1999;51:108-15. It is found in certain foods and it can also be taken as tablets. View abstract. View abstract. J Nutr 2002;132(8 Suppl):2367S-2372S. Int J Cancer. Leucovorin calcium [package insert]. Stehouwer CD. Folic acid is the synthetic version of folate, an essential vitamin. View abstract. Basu, R. N., Sood, S. K., Ramachandran, K., Mathur, M., and Ramalingaswami, V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Spoelstra-de, M. A., Brouwer, C. B., Terheggen, F., Bollen, J. M., Stehouwer, C. D., and Smulders, Y. M. No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia. 1990;10(3):149-152. Pediatrics 1980;65(4):683-697. View abstract. J Gerontol.A Biol.Sci Med Sci 2005;60(9):1190-1201. Shrubsole, M. J., Shu, X. O., Li, H. L., Cai, H., Yang, G., Gao, Y. T., Gao, J., and Zheng, W. Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women. ⓘ If you buy something after visiting a link below, we get a commission. High levels of homocysteine have been linked to heart disease and stroke. 2007;59(3):281-297. View abstract. ERJ Open Res. Ziegler, S., Mittermayer, F., Plank, C., Minar, E., Wolzt, M., and Schernthaner, G. H. Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease. View abstract. Folic acid is used to increase levels of folate in the body, which can have a variety of benefits. Some research shows that taking folic acid supplements during the last 22 weeks of pregnancy may improve the child's mental function during childhood. View abstract. QJM. The Canadian Task Force on Preventive Health Care. Shafer RB, Nuttall FQ. Botez MI, Peyronnard J, Berube L, Labrecque R. Relapsing neuropathy, cerebral atrophy and folate deficiency. Sombolos, K., Papaioannou, A., Christidou, F., Natse, T., Bamichas, G., Gionanlis, L., Katsaris, G., and Progia, E. The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients. Bostom AG, Shemin D, Gohh RY, et al. B., Rich, S. S., Matarin, M., Norman, P. E., Flicker, L., Almeida, O. P., van Bockxmeer, F. M., Shimokata, H., Khaw, K. T., Wareham, N. J., Bobak, M., Sterne, J. View abstract. View abstract. Cleft lip and cleft palate. View abstract. View abstract. Evans DI, Attock B. Folate deficiency in pulmonary tuberculosis: relationship to treatment and to serum vitamin A and beta carotene. May 2001. Final report. 2017;35(6):1302-1309. 1986;80(2):211-233. View abstract. The role of homocysteine in multisystem age-related problems: a systematic review. View abstract. Limited research suggests taking folic acid during pregnancy might reduce the risk of autism in the child. Berry-Kravis, E., Krause, S. E., Block, S. S., Guter, S., Wuu, J., Leurgans, S., Decle, P., Potanos, K., Cook, E., Salt, J., Maino, D., Weinberg, D., Lara, R., Jardini, T., Cogswell, J., Johnson, S. A., and Hagerman, R. Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. van der Zwaluw NL, Dhonukshe-Rutten RA, van Wijngaarden JP, et al. View abstract. Am Heart J 2007;154(5):815-23, 823. Am.J.Clin Nutr. Li M, Li W, Gao Y, et al. Negrao L, Almeida P, Alcino S, et al. Where did you or where do you plan to purchase this product? View abstract. Liu J, Li Z, Ye R, Liu J, Ren A. Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4-6 years of age. Cochrane Database Syst Rev. Int J Cancer 7-1-2011;129(1):192-203. View abstract. Voutilainen S, Lakka TA, Porkkala-Sarataho E, et al. View abstract. Ophthalmology 2012;119(12):2493-2499. Paediatr.Perinat.Epidemiol. Olsen SF, Sorensen JD, Secher NJ, et al. View abstract. Blood 1971;38:405-16. Oral contraceptives: effect on folate and vitamin B12 metabolism. Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet. A prospective study of plasma homocyst(e)ine and risk of ischemic stroke. View abstract. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Taliani U, Camellini A, Bernardi P, et al. Accumulation of this compound may increase the risk of strokes and heart disease. A., Kew, C., McKenney, J. L., Pacheco-Silva, A., Pesavento, T., Pirsch, J., Smith, S., Solomon, S., and Weir, M. Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. N Eng J Med 2000;342:1946-52. Xu X, Qin X, Li Y, et al; Investigators of the Renal Substudy of the China Stroke Primary Prevention Trial (CSPPT). Association between folate intake and risk of head and neck squamous cell carcinoma: An overall and dose-response PRISMA meta-analysis. Lancet 7-6-2002;360(9326):23-33. Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial. View abstract. Russell RM, Golner BB, Krasinski SD, et al. Lancet Neurol. 2011;93(5):941-949. Ford, A. H., Flicker, L., Thomas, J., Norman, P., Jamrozik, K., and Almeida, O. P. Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial. Since its establishment in 1973 in Utah, Solaray has pioneered encapsulated dietary supplement formulations. Carpentier JL, Bury J, Luyckx A, et al. View abstract. Hanrahan, P. S. and Russell, A. S. Concurrent use of folinic acid and methotrexate in rheumatoid arthritis. A. Wang, Z. M., Zhou, B., Nie, Z. L., Gao, W., Wang, Y. S., Zhao, H., Zhu, J., Yan, J. J., Yang, Z. J., and Wang, L. S. Folate and risk of coronary heart disease: a meta-analysis of prospective studies. JAMA. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance. Ronsmans C., Fisher D. J., Osmond C., Margetts B. M., Fall C. H. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality. Godwin, K. A., Sibbald, B., Bedard, T., Kuzeljevic, B., Lowry, R. B., and Arbour, L. Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registry. Lajous, M., Romieu, I., Sabia, S., Boutron-Ruault, M. C., and Clavel-Chapelon, F. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Taking a daily vitamin supplement that has folic acid can reduce the risk of your baby having a neural tube defect. Long-term consumption of folic acid in high doses may be associated with diarrhea, headache, confusion, skin reactions, asthma attacks, seizures, and heart disease. Kaisar, M., Isbel, N., and Johnson, D. W. Cardiovascular disease in patients with chronic kidney disease. B. Levi, F., Pasche, C., Lucchini, F., and La Vecchia, C. Dietary intake of selected micronutrients and breast-cancer risk. Effects of iron and folic acid antenatal supplements on maternal haematology and fetal wellbeing. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. By continuing to browse, you agree to the use of these cookies. View abstract. POSITIVE. Br J Nutr 2006;96(1):182-190. Am J Psychiatry 1997;154:426-8. View abstract. View abstract. View abstract. Solgar has cemented its position as an industry leader, incorporating state-of-the-art facilities and exceeding the requirements of GMP. View abstract. Traccis S, Monaco F, Sechi GP, et al. 2017;354(4):379-387. Van, Loon K. and Venook, A. P. Adjuvant treatment of colon cancer: what is next? Get more details in the recent update to the folic acid section of the B Vitamins Review >> Higher Vitamin Level May Slow Cognitive Decline . View abstract. Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial. View abstract. Jacques, P. F., Selhub, J., Bostom, A. G., Wilson, P. W., and Rosenberg, I. H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. Birth Defects Res A Clin Mol.Teratol. Nerve pain in people with diabetes (diabetic neuropathy). In contrast with the naturally occurring folate, folic acid is the synthetic form that is present in supplements and vitamin B9-fortified foods (cereals, flour, pasta, etc). Is high homocysteine level a risk factor for cognitive decline in elderly? Kral, V. A., Solyom, L., Enesco, H., and Ledwidge, B. Eur J Vasc.Endovasc.Surg 2009;38(3):316-322. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Figueiredo JC, Grau MV, Haile RW, et al. Sharp, L., Little, J., Schofield, A. C., Pavlidou, E., Cotton, S. C., Miedzybrodzka, Z., Baird, J. O., Haites, N. E., Heys, S. D., and Grubb, D. A. Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Paediatr.Perinat.Epidemiol. View abstract. Colon cancer, rectal cancer. J Am Coll Cardiol 1996;27:517-27. Ray, J. G., Kearon, C., Yi, Q., Sheridan, P., and Lonn, E. Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Solfrizzi, V., Colacicco, A. M., D'Introno, A., Capurso, C., Del, Parigi A., Capurso, S. A., Argentieri, G., Capurso, A., and Panza, F. Dietary fatty acids intakes and rate of mild cognitive impairment. Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Heart disease. Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. A. View abstract. View abstract. View abstract. Liem, A. H., van Boven, A. J., Veeger, N. J., Withagen, A. J., Robles de Medina, R. M., Tijssen, J. G., and van Veldhuisen, D. J. Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial. Ionescu-Ittu, R., Marelli, A. J., Mackie, A. S., and Pilote, L. Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada. Benamouzig, R., Deyra, J., Martin, A., Girard, B., Jullian, E., Piednoir, B., Couturier, D., Coste, T., Little, J., and Chaussade, S. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Oral magnesium supplementation and the prevention of preterm labor. Folate is a type of B vitamin. Wald, D. S., Kasturiratne, A., and Simmonds, M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Stevens, D., Burman, D., Strelling, M. K., and Morris, A. Folic acid supplementation in low birth weight infants. View abstract. 1979;58(4):343-346. But opting out of some of these cookies may have an effect on your browsing experience. J Natl.Cancer Inst. Am J Clin Nutr 2009;89(1):216-220. 2011;23(2):192-202. View abstract. Int J Gynaecol.Obstet. 2011;137(6):927-938. A. Homocysteine, vitamins, and vascular disease prevention: more negative results. Godfrey PS, Toone BK, Carney MW, et al. In particular, red blood cell formation is dependent upon adequate levels of this vitamin. Chest 1984;86:149-50. It’s a man-made version of folate, a naturally occurring B vitamin found in many foods. Mendez-Gonzalez, J., Rodriguez-Millan, E., Julve, J., and Blanco-Vaca, F. [Vitamin treatments that lower homocysteine concentration: can they decrease cerebrovascular disease in primary prevention?]. Public Health Nutr 1998;1(3):147-156. Sayed, A. R., Bourne, D., Pattinson, R., Nixon, J., and Henderson, B. View abstract. Zhou, K., Zhao, R., Geng, Z., Jiang, L., Cao, Y., Xu, D., Liu, Y., Huang, L., and Zhou, J. View abstract. A randomized trial of aspirin to prevent colorectal adenomas. Gastroenterology. Wang Y, Jin Y, Wang Y, Li L, Liao Y, Zhang Y, Yu D. The effect of folic acid in patients with cardiovascular disease: A systematic review and meta-analysis. View abstract. Fruzzetti, F. Beyaz(R): an oral contraceptive fortified with folate. Bailey, L. B. A skin disorder that causes white patches to develop on the skin (vitiligo). However it will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Indian Heart J 2000;52(7 Suppl):S59-S64. View abstract. A., Devlin, A. M., and Chandler, C. J. Metabolic interactions of alcohol and folate. Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., and Tsugane, S. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Dig Dis Sci 1980;25:369-73. View abstract. Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions. 2008;28(6):503-523. View abstract. Annu.Rev Nutr 8-21-2010;30:83-104. Your body also needs folic acid to make normal red blood cells and prevent a type of anemia (folate-deficiency anemia). View abstract. Int.J.Food Sci.Nutr. View abstract. Gout. Cancer Causes Control 2003;14(9):827-836. Exp.Clin Transplant. Samuel, P. D., Burland, W. L., and Simpson, K. Response to oral administration of pteroylmonoglutamic acid or pteroylpolyglutamate in newborn infants of low birth weight. Botez MI, Cadotte M, Beaulieu R, et al. The nutrition of expectant and nursing mothers in relation to maternal and infant mortality and morbidity. As the name suggests, this folic acid supplement is pure folic acid with no added ingredients! Woodman, R. J., Celermajer, D. E., Thompson, P. L., and Hung, J. Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects. Stock C. Trimethoprim-sulfamethoxazole and folinic acid (letter). Stroke 2012;43(6):1572-7. Arch Dis Child 1996;74:157-60. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Available at: www.nap.edu/books/0309072794/html/. Beaulieu AJ, Gohh RY, Han H, et al. View abstract. Cancer Epidemiol Biomarkers Prev 2002;11:630-9.. View abstract. A., Yakoob, M. Y., and Bhutta, Z. Zintzaras, E. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. Kile, M. L. and Ronnenberg, A. G. Can folate intake reduce arsenic toxicity? Br.J Surg. View abstract. Nallamothu BK, Fendrick M, Rubenfire M, et al. Folic acid as an adjunct in the treatment of children with the autism fragile-X syndrome (AFRAX). A., Wrigley, J., Refsum, H., and Kooner, J. S. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Eur.J.Clin Nutr. The effect of different treatment regimens in reducing fasting and postmethionine-load homocysteine concentrations. 1946;53(6):498-509. Phenytoin-folic acid interaction. View abstract. van der Dijs FP, Fokkema MR, Dijck-Brouwer DA, et al. View abstract. 12-1-2004;96(23):1743-1750. Am J Med Genet. View abstract. Ericson, U. C., Ivarsson, M. I., Sonestedt, E., Gullberg, B., Carlson, J., Olsson, H., and Wirfalt, E. Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele. View abstract. View abstract. 1994;20(6):933-940. Researchers are studying whether folic acid deficiency causes restless legs syndrome. View abstract. 2000. Lambie DG, Johnson RH. Arber, N., Eagle, C. J., Spicak, J., Racz, I., Dite, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., Rosenstein, R. B., Macdonald, K., Bhadra, P., Fowler, R., Wittes, J., Zauber, A. G., Solomon, S. D., and Levin, B. Celecoxib for the prevention of colorectal adenomatous polyps. 2009;38(6):682-684. Serum folate and chronic fatigue syndrome. Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients. Russell RM, Krasinski SD, Samloff IM, et al. Beta-thalassemia is a disorder of the blood that results in the production of less hemoglobin, the protein that carries oxygen in the blood. View abstract. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. Proc Greenwood Genet Center 2007;26:40-44. View abstract. 2004;13(2):190-196. Seller, M. J. and Nevin, N. C. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. Effects occur while taking folic acid folic acid tablets pregnancy does not seem to reduce risk. Negrao L, Almeida P, et al opting out of some these. 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